臨床研究センター

先端医療技術開発研究室

2018年　国際学会・国内学会・研究会　発表

講演会

平成29年度AMED 4事業合同成果報告会 2018年2月13日 東京

【講演Ⅱ】循環器疾患・糖尿病等生活習慣病対策実用化研究事業
慢性腎臓病における心血管イベント予測のための血液バイオマーカー開発を目的とした国立病院機構多施設共同前向きコホート研究
和田　啓道（京都医療センター）

国際学会

World Congress of Cardiology & Cardiovascular Health 2018, 3-8 Dec, Dubai, UAE (4演題)

1. Maki Komiyama, Hiromichi Wada, Hajime Yamakage, Noriko Sato-Asahara, Akira Shimatsu Shimatsu, Tatsuya Morimoto, Yuko Takahashi, Koji Hasegawa.
   THE EFFECTS OF ABDOMINAL OBESITY ON THE CHANGES IN SERUM ADIPONECTIN LEVELS AFTER SMOKING CESSATION (WCC2018-ABS-1106)
2. Sayaka Shimada, Maki Komiyama, Yuka Ozaki, Hiromichi Wada, Hajime Yamakage, Yoichi Sunagawa, Tatsuya Morimoto, Yuko Takahashi, Koji Hasegawa.
   ANALYSIS ON CHANGES IN THE DIFFERENTIAL LEUKOCYTE COUNT AFTER SMOKING CESSATION (WCC2018-ABS-1660)
3. Maki Komiyama, Yusuke Miyazaki, Hiromichi Wada, Mitsuru Abe, Hisashi Ogawa, Masaharu Akao, Noriko Satoh-Asahara, Yoichi Sunagawa, Tatsuya Morimoto, Koji Hasegawa.
   ANALYSIS OF INDICES OF APIXABAN ANTICOAGULATION (WCC2018-ABS-1745)
4. Sayaka Shimada, Maki Komiyama, Hiromichi Wada, Hajime Yamakage, Yuka Ozaki, Tatsuya Morimoto, Akira Shimatsu, Yuko Takahashi, Koji Hasegawa.
   ANALYSIS OF GENDER DIFFERENCES IN SMOKERS REGARDING THE RELATIONSHIP BETWEEN DEPRESSIVE TENDENCY AND NICOTINE DEPENDENCY (WCC2018-ABS-1771)

American Heart Association Scientific Sessions 2018, Nov 10–12, 2018, Chicago, IL, USA (18演題)

1. Hiromichi Wada, Masahiro Suzuki, Morihiro Matsuda, Yoichi Ajiro, Tsuyoshi Shinozaki, Satoru Sakagami, Kazuya Yonezawa, Masatoshi Shimizu, Junichi Funada, Takashi Takenaka, Yukiko Morita, Toshihiro Nakamura, Kazuteru Fujimoto, Hiromi Matsubara, Toru Kato, Takashi Unoki, Daisuke Takagi, Shuichi Ura, Kyohma Wada, Moritake　Iguchi, Nobutoyo Masunaga, Mitsuru Ishii, Hajime Yamakage, Akira Shimatsu, Kazuhiko Kotani, Noriko Satoh-Asahara, Mitsuru Abe, Masaharu Akao, and Koji Hasegawa. Vascular Endothelial Growth Factor-D and Mortality in Patients With Suspected or Known Coronary Artery Disease: From the ANOX Study. CirculationVolume 138, Issue Suppl_1 (Abstract 12953) (Nov 10, 2018)
2. Hiromichi Wada, Masahiro Suzuki, Morihiro Matsuda, Yoichi Ajiro, Tsuyoshi Shinozaki, Satoru Sakagami, Kazuya Yonezawa, Masatoshi Shimizu, Junichi Funada, Takashi Takenaka, Yukiko Morita, Toshihiro Nakamura, Kazuteru Fujimoto, Hiromi Matsubara, Toru Kato, Takashi Unoki, Daisuke Takagi, Shuichi Ura, Kyohma Wada, Moritake　Iguchi, Nobutoyo Masunaga, Mitsuru Ishii, Hajime Yamakage, Akira Shimatsu, Kazuhiko Kotani, Noriko Satoh-Asahara, Mitsuru Abe, Masaharu Akao, and Koji Hasegawa. Vascular Endothelial Growth Factor-C and Mortality in Patients With Stable Coronary Heart Disease: A Subanalysis of the ANOX Study. CirculationVolume 138, Issue Suppl_1 (Abstract 12973) (Nov 10, 2018)
3. Hiromichi Wada, Masahiro Suzuki, Morihiro Matsuda, Yoichi Ajiro, Tsuyoshi Shinozaki, Satoru Sakagami, Kazuya Yonezawa, Masatoshi Shimizu, Junichi Funada, Takashi Takenaka, Yukiko Morita, Toshihiro Nakamura, Kazuteru Fujimoto, Hiromi Matsubara, Toru Kato, Takashi Unoki, Daisuke Takagi, Shuichi Ura, Kyohma Wada, Moritake　Iguchi, Nobutoyo Masunaga, Mitsuru Ishii, Hajime Yamakage, Akira Shimatsu, Kazuhiko Kotani, Noriko Satoh-Asahara, Mitsuru Abe, Masaharu Akao, and Koji Hasegawa. Growth Differentiation Factor-15 Predicts Mortality and Cardiovascular Events in Patients With Diabetes and Stable Coronary Heart Disease: A Subanalysis From the ANOX Study. CirculationVolume 138, Issue Suppl_1 (Abstract 14389) (Nov 10, 2018)
4. Hiromichi Wada, Masahiro Suzuki, Morihiro Matsuda, Yoichi Ajiro, Tsuyoshi Shinozaki, Satoru Sakagami, Kazuya Yonezawa, Masatoshi Shimizu, Junichi Funada, Takashi Takenaka, Yukiko Morita, Toshihiro Nakamura, Kazuteru Fujimoto, Hiromi Matsubara, Toru Kato, Takashi Unoki, Daisuke Takagi, Shuichi Ura, Kyohma Wada, Moritake　Iguchi, Nobutoyo Masunaga, Mitsuru Ishii, Hajime Yamakage, Akira Shimatsu, Kazuhiko Kotani, Noriko Satoh-Asahara, Mitsuru Abe, Masaharu Akao, and Koji Hasegawa. Growth Differentiation Factor-15 Predicts Mortality in Patients With Chronic Kidney Disease and Stable Coronary Heart Disease: A Subanalysis of the ANOX Study. CirculationVolume 138, Issue Suppl_1 (Abstract 14440) (Nov 10, 2018)
5. Hiromichi Wada, Masahiro Suzuki, Morihiro Matsuda, Yoichi Ajiro, Tsuyoshi Shinozaki, Satoru Sakagami, Kazuya Yonezawa, Masatoshi Shimizu, Junichi Funada, Takashi Takenaka, Yukiko Morita, Toshihiro Nakamura, Kazuteru Fujimoto, Hiromi Matsubara, Toru Kato, Takashi Unoki, Daisuke Takagi, Shuichi Ura, Kyohma Wada, Moritake　Iguchi, Nobutoyo Masunaga, Mitsuru Ishii, Hajime Yamakage, Akira Shimatsu, Kazuhiko Kotani, Noriko Satoh-Asahara, Mitsuru Abe, Masaharu Akao, and Koji Hasegawa. Sex Difference in the Associations of Omega-6 Polyunsaturated Fatty Acids With Mortality in Patients With Stable Coronary Heart Disease: A Subanalysis of the ANOX Study. CirculationVolume 138, Issue Suppl_1 (Abstract 15241) (Nov 11, 2018)
6. Moritake Iguchi, Masahiro Suzuki, Morihiro Matsuda, Yoichi Ajiro, Tsuyoshi Shinozaki, Satoru Sakagami, Kazuya Yonezawa, Masatoshi Shimizu, Junichi Funada, Takashi Takenaka, Yukiko Morita, Toshihiro Nakamura, Kazuteru Fujimoto, Hiromi Matsubara, Toru Kato, Takashi Unoki, Daisuke Takagi, Shuichi Ura, Kyoma Wada, Nobutoyo Masunaga, Mitsuru Ishii, Hajime Yamakage, Akira Shimatsu, Kazuhiko Kotani, Noriko Satoh-Asahara, Mitsuru Abe, Masaharu Akao, Koji Hasegawa, and Hiromichi Wada. Low Vascular Endothelial Growth Factor-c Was a Predictor for Cardiovascular Events in Patients With Atrial Fibrillation: A Subanalysis of the Anox Study. CirculationVolume 138, Issue Suppl_1 (Abstract 15574) (Nov 11, 2018)
7. Moritake Iguchi, Masahiro Suzuki, Morihiro Matsuda, Yoichi Ajiro, Tsuyoshi Shinozaki, Satoru Sakagami, Kazuya Yonezawa, Masatoshi Shimizu, Junichi Funada, Takashi Takenaka, Yukiko Morita, Toshihiro Nakamura, Kazuteru Fujimoto, Hiromi Matsubara, Toru Kato, Takashi Unoki, Daisuke Takagi, Shuichi Ura, Kyoma Wada, Nobutoyo Masunaga, Mitsuru Ishii, Hajime Yamakage, Akira Shimatsu, Kazuhiko Kotani, Noriko Satoh-Asahara, Mitsuru Abe, Masaharu Akao, Koji Hasegawa, and Hiromichi Wada. Vascular Endothelial Growth Factor-C and Mortality in Patients With Stable Coronary Artery Disease and a History of Heart Failure: A Subanalysis of the ANOX Study. CirculationVolume 138, Issue Suppl_1 (Abstract 15881) (Nov 11, 2018)
8. Moritake Iguchi, Masahiro Suzuki, Morihiro Matsuda, Yoichi Ajiro, Tsuyoshi Shinozaki, Satoru Sakagami, Kazuya Yonezawa, Masatoshi Shimizu, Junichi Funada, Takashi Takenaka, Yukiko Morita, Toshihiro Nakamura, Kazuteru Fujimoto, Hiromi Matsubara, Toru Kato, Takashi Unoki, Daisuke Takagi, Shuichi Ura, Kyoma Wada, Nobutoyo Masunaga, Mitsuru Ishii, Hajime Yamakage, Akira Shimatsu, Kazuhiko Kotani, Noriko Satoh-Asahara, Mitsuru Abe, Masaharu Akao, Koji Hasegawa, and Hiromichi Wada. Vascular Endothelial Growth Factor-C and Mortality in Patients With Stable Coronary Artery Disease and Cancer: A Subanalysis of the ANOX Study. CirculationVolume 138, Issue Suppl_1 (Abstract 16719) (Nov 11, 2018)
9. Yasufumi Katanasaka, Yusuke Miyazaki, Yoichi Sunagawa, Hiromichi Wada, Koji Hasegawa, and Tatsuya Morimoto. Cacao Bean Polyphenols Inhibits Cardiac Hypertrophy and Dysfunction in Pressure Overload-Induced Heart Failure Model. CirculationVolume 138, Issue Suppl_1 (Abstract 15578)
10. Nobutoyo Masunaga, Moritake Iguchi, Mitsuru Ishii, Yoshimori An, Masahiro Esato, Hiromichi Wada, Koji Hasegawa, Hisashi Ogawa, Mitsuru Abe, and Masaharu Akao. Year-by-year Change of Combination Therapy With Oral Anticoagulant and Antiplatelet Drug for Atrial Fibrillation Patients Since 2011: The Fushimi AF Registry. CirculationVolume 138, Issue Suppl_1 (Abstract 13365)
11. Mitsuru Ishii, Hisashi Ogawa, Nobutoyo Masunaga, Moritake Iguchi, Yoshimori An, Masahiro Esato, Hiromichi Wada, Koji Hasegawa, Mitsuru Abe, and Masaharu Akao. Risk Factors for Intracranial Hemorrhage and Extracranial Hemorrhage in Patients With Atrial Fibrillation: The Fushimi AF Registry. CirculationVolume 138, Issue Suppl_1 (Abstract 14474)
12. Masafumi Funamoto, Yoichi Sunagawa, Yasufumi Katanasaka, Kana Shimizu, Yusuke Miyazaki, Nurmila Sari, Satoshi Shimizu, Hiromichi Wada, Koji Hasegawa, and Tatsuya Morimoto. Histone H3 Globular Domain Acetylation is Promoted by the Interaction of P300 With BRG1 During the Transition From Cardiac Hypertrophy to Heart Failure. CirculationVolume 138, Issue Suppl_1 (Abstract 15609)
13. Moritake Iguchi, Nobutoyo Masunaga, Mitsuru Ishii Ishii, Yoshimori An, Masahiro Esato, Hiromichi Wada, Koji Hasegawa, Hisashi Ogawa, Mitsuru Abe, and Masaharu Akao. Risk Factors of Heart Failure Events in Atrial Fibrillation With Preserved, Mid-Range, and Reduced Left Ventricular Ejection Fraction: The Fushimi AF Registry. CirculationVolume 138, Issue Suppl_1 (Abstract 13376)
14. Kana Shimizu, Masafumi Funamoto, Yoichi Sunagawa, Yasufumi Katanasaka, Yusuke Miyazaki, Mai Genpei, Satoshi Shimizu, Nurmila Sari, Hiroyuki Shibata, Hiromichi Wada, Koji Hasegawa, and Tatsuya Morimoto. The Curcumin Analogue GO-Y030 Effectively Suppresses Cardiac Hypertrophy and Systolic Dysfunction Through p300-HAT Inhibition. CirculationVolume 138, Issue Suppl_1 (Abstract 17094)
15. Satoshi Shimizu, Yoichi Sunagawa, Kodai Hara, Asami Hishiki, Yasufumi Katanasaka, Yusuke Miyazaki, Masafumi Funamoto, Nurmila Sari, Kana Shimizu, Hiromichi Wada, Koji Hasegawa, Hiroshi Hashimoto, and Tatsuya Morimoto. Inhibition of GATA4 Dimerization Suppresses Hypertrophic Responses in Cardiomyocytes. CirculationVolume 138, Issue Suppl_1 (Abstract 12967)
16. Yuya Aono, Moritake Iguchi, Syuhei Ikeda, Kosuke Doi, Yoshimori An, Mitsuru Ishii, Nobutoyo Masunaga, Masahiro Esato, Hiromichi Wada, Koji Hasegawa, Hisashi Ogawa, Mitsuru Abe, and Masaharu Akao. Risk Factors of New-Onset Heart Failure in Patients With Atrial Fibrillation Patients Without Pre-Existing Organic Heart Disease: The Fushimi AF Registry. CirculationVolume 138, Issue Suppl_1 (Abstract 13354)
17. Syuhei Ikeda, Moritake Iguchi, Yuya Aono, Kosuke Doi, Yoshimori An, Mitsuru Ishii, Nobutoyo Masunaga, Masahiro Esato, Hiromichi Wada, Koji Hasegawa, Hisashi Ogawa, Mitsuru Abe, and Masaharu Akao. The Characteristics and Outcomes of the Elderly Atrial Fibrillation Patients With or Without Oral Anticoagulants in Japanese Clinical Practice: The Fushimi AF Registry. CirculationVolume 138, Issue Suppl_1 (Abstract 13355)
18. Hisashi Ogawa, Yoshimori An, Moritake Iguchi, Kenjiro Ishigami, Yuya Aono, Syuhei Ikeda, Kosuke Doi, Mitsuru Ishii, Nobutoyo Masunaga, Masahiro Esato, Hiromichi Wada, Koji Hasegawa, Mitsuru Abe, and Masaharu Akao. Characteristics and Clinical Outcomes in Patients With Atrial Fibrillation Classified by Cluster Analysis: The Fushimi AF Registry. CirculationVolume 138, Issue Suppl_1 (Abstract 13280)

European Society of Cardiology Congress 2018, Aug 25-29, Munich, Germany (10演題)

1. H Wada, T Shinozaki, M Suzuki, S Sakagami, Y Ajiro, J Funada, M Matsuda, M Shimizu, T Takenaka, Y Morita, K Kotani, N Satoh-Asahara, M Abe, M Akao, K Hasegawa, the EXCEED-J study investigators. Diagnostic utility of biomarkers to predict coronary artery disease in patients with and without chronic kidney disease: baseline data from the EXCEED-J study. European Heart Journal, Volume 39, Issue suppl_1, 1 August 2018, ehy565.P2720, https://doi.org/10.1093/eurheartj/ehy565.P2720. Published: 28 August 2018
2. H Wada, M Suzuki, M Matsuda, Y Ajiro, T Shinozaki, S Sakagami, K Yonezawa, M Shimizu, J Funada, T Takenaka, Y Morita, K Wada, M Abe, M Akao, K Hasegawa; the ANOX study investigators. Vascular endothelial growth factor-C and cardiovascular mortality in patients with suspected and a history of coronary artery disease: from the ANOX study. European Heart Journal, Volume 39, Issue suppl_1, 1 August 2018, ehy566.P6253, https://doi.org/10.1093/eurheartj/ehy566.P6253. Published: 28 August 2018
3. D Takagi, M Suzuki, M Matsuda, Y Ajiro, T Shinozaki, S Sakagami, K Yonezawa, M Shimizu, J Funada, T Takenaka, Y Morita, M Abe, M Akao, K Hasegawa, H Wada; the ANOX study investigators. Vascular endothelial growth factor-C and cardiovascular and all-cause mortality in patients with chronic kidney disease and suspected coronary artery disease: from the ANOX study. European Heart Journal, Volume 39, Issue suppl_1, 1 August 2018, ehy566.P5336, https://doi.org/10.1093/eurheartj/ehy566.P5336. Published: 28 August 2018
4. T Unoki, M Suzuki, M Matsuda, Y Ajiro, T Shinozaki, S Sakagami, K Yonezawa, M Shimizu, J Funada, T Takenaka, Y Morita, M Abe, M Akao, K Hasegawa, H Wada; the ANOX study investigators. Vascular endothelial growth factor-C and mortality in patients with diabetes and suspected coronary artery disease: from the ANOX study. European Heart Journal, Volume 39, Issue suppl_1, 1 August 2018, ehy565.P2520, https://doi.org/10.1093/eurheartj/ehy565.P2520. Published: 28 August 2018
5. M Abe, H Ogawa, S Ikeda, Y Aono, K Doi, Y An, M Ishii, M Iguchi, N Masunaga, M Esato, H Tsuji, H Wada, K Hasegawa, M Akao; the Fushimi AF Registry investigators. The incidence and risk factors of percutaneous coronary intervention procedures in patients with atrial fibrillation: the fushimi AF registry. European Heart Journal, Volume 39, Issue suppl_1, 1 August 2018, ehy565.P1649, https://doi.org/10.1093/eurheartj/ehy565.P1649. Published: 28 August 2018
6. M Esato, Y An, H Wada, K Hasegawa, H Tsuji, H Ogawa, M Abe, M Akao; Fushimi AF Registry. Impact of atrial fibrillation catheter ablation on the long-term clinical outcome: A propensity score matched analysis from the Fushimi AF Registry. European Heart Journal, Volume 39, Issue suppl_1, 1 August 2018, ehy565.P2875, https://doi.org/10.1093/eurheartj/ehy565.P2875. Published: 28 August 2018
7. K Doi, M Iguchi, H Ogawa, M Esato, H Wada, K Hasegawa, M Abe, M Akao. Clinical characteristics and outcomes of japanese patients with atrial fibrillation and mitral regurgitation: the fushimi af registry. European Heart Journal, Volume 39, Issue suppl_1, 1 August 2018, ehy564.P1008, https://doi.org/10.1093/eurheartj/ehy564.P1008. Published: 28 August 2018
8. M Ishii, H Ogawa, Y Aono, S Ikeda, K Doi, Y An, M Iguchi, N Masunaga, M Esato, H Wada, K Hasegawa, M Abe, M Akao. Relationship between diabetes mellitus and a risk of heart failure hospitalization in patients with atrial fibrillation: the Fushimi AF registry. European Heart Journal, Volume 39, Issue suppl_1, 1 August 2018, ehy564.P977, https://doi.org/10.1093/eurheartj/ehy564.P977. Published: 28 August 2018
9. S Ikeda, M Iguchi, Y Aono, K Doi, Y An, M Ishii, N Masunaga, M Esato, H Wada, K Hasegawa, H Ogawa, M Abe, M Akao; the Fushimi AF Registry. Impact of proteinuria on cardiovascular outcomes in Japanese patients with atrial fibrillation: the Fushimi AF Registry. European Heart Journal, Volume 39, Issue suppl_1, 1 August 2018, ehy566.P6026, https://doi.org/10.1093/eurheartj/ehy566.P6026. Published: 28 August 2018
10. Y An, M Iguchi, Y Aono, S Ikeda, K Doi, M Ishii, N Masunaga, M Esato, H Tsuji, H Wada, K Hasegawa, H Ogawa, M Abe, M Akao; the Fushimi AF Registry investigators. Prognostic impact of paroxysmal versus sustained atrial fibrillation on the incidence of cardiac death and heart failure hospitalization:The Fushimi AF Registry. European Heart Journal, Volume 39, Issue suppl_1, 1 August 2018, ehy566.P6591, https://doi.org/10.1093/eurheartj/ehy566.P6591. Published: 28 August 2018

The 23rd Annual Scientific Meeting of International Society of Cardiovascular pharmacotherapy 2018年05月26-27日 Kyoto, Japan（24演題）

1. Nobutoyo Masunaga, Shuichi Ura, Mitsuru Ishii, Takashi Unoki, Daisuke Takagi, Moritake Iguchi, Kensuke Takabayashi, Yugo Yamashita, Yasuhiro Hamatani, Hisashi Ogawa, Noriko Satoh-Asahara, Akira Shimatsu, Mitsuru Abe, Masaharu Akao, Koji Hasegawa, Hiromichi Wada
   Relationchip between VEGF-C levels and mortality in patients with peripheral artery disease (P06)
2. Takashi Unoki, Shuichi Ura, Daisuke Takagi, Nobutoyo Masunaga, Mitsuru Ishii, Moritake Iguchi, Kensuke Tatakabayashi, Yugo Yamashita, Yasuhiro Hamatani, Hisashi Ogawa, Noriko Satoh-Asahara, Akira Shimatsu, Mitsuru Abe, Masaharu Akao, Koji Hasegawa, Hiromichi Wada
   VEGF-C and cardiovascular mortality in patients undergoing drug-eluting stent implantation (P07)
3. Hikaru Moki, Satoshi Shimizu, Yoichi Sunagawa, Yusuke Miyazaki, Masafumi Funamoto, Nurmila Sari, Kana Shimizu, Yasufumi Katanasaka, Naohisa Ogo, Akira Asai, Hiromichi Wada, Koji Hasegawa, Tetsuya Morimoto
   Development of a high throughput imaging assay for the discovery of anti-hypertrophy agents (P09)
4. Satoshi Shimizu, Yoishi Sunagawa, Kodai Hara, Asami Hishiki, Masafumi Funamoto, Sari Nurmila, Kana Shimizu, Yusuke Miyazaki, Yasufumi Katanasaka, Hiromichi Wada, Koji Hasegawa, Hiroshi Hashimoto, Tetsuya Morimoto
   The GATA4 acetylation site plays a key role in the development of cardiomyocyte hypertrophy (P10)
5. Mari Gempei, Yoishi Sunagawa, Masafumi Funamoto, Yasufumi Katanasaka, Yusuke Miyazaki, Kana Shimizu, Nurmila Sari, Satoshi Shimizu, Nobuaki Takahashi, Hideaki Kakeya, Hiromichi Wada, Akira Shimatsu, Koji Hasegawa, Tetsuya Morimoto
   Inhibitory Effects of Curcumin Derivatives on Hypertrophic Responses in Cultured Cardiomyocytes (P13)
6. Kana Shimizu, Masafumi Funamoto, Youichi Sunagawa, Hiroki Wakabayashi, Yasufumi Katanasaka, Yusuke Miyazaki, Mai Genpei, Satoshi Shimizu, Numira Sari, Hiroyuki Shibata, Hiromichi Wada, Koji Hasegawa, Tetsuya Morimoto
   The potent p300-HAT inhibitor GO-Y30 suppresses TAC-induced heart failure in vivo (P15)
7. Yasufumi Katanasaka, Masatoshi Namiki, Yoichi Sunagawa, Yusuke Miyazaki, Hiromichi Wada, Koji Hasegawa, Tetsuya Morimoto
   TBL1 suppresses cardiomyocyte hypertrophy by regulating the interaction between HDAC3 and GATA4 (P16)
8. Hana Sasaki, Yoichi Sunagawa, Anna Suzuki, Funamoto Masafumi, Kana Simizu, Yasufumi Katanasaka, Yusuke Miyazaki, Satoshi Shimizu, Sari Nurmila, Akira Murakami, Asakawa Tomohiro, Kan Toshiyuki, Hiromichi Wada, Akira Shimizu, Koji Hasegawa, Tatsuya Morimoto
   Synthetic NobiletinInhibits the Development of Heart Faiure to the Same Extent as Natural Nobiletin (P18)
9. Noriyuki Murata, Hikaru Sato, Yasufumi Katanasaka, Yusuke Miyazaki, Yoichi Sunagawa, Masafumi Funamoto, Nurmila Sari, Kana Shimizu, Satoshi Shimizu, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
   WDR5/MLL1 inhibitor MM102 suppresses the kirrerentiation of cardiac fibroblasts to myofibroblasts (P19)
10. Masafumi Funamoto, Yoichi Sunagawa, Yasufumi Katanasaka, Kana Shimizu, Yusuke Miyazaki, Nurmila Sari, Satoshi Shimizu, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
    The interaction of p300 and BRG1 Altered the Acetylated Sites of Histone H3 in Heart Failure (P20)
11. Yosuke Nagai, Yasufumi Katanasaka, Nana Amano, Yoichi Sunagawa, Yusuke Miyazaki, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
    WD repeat-containing protein 5 inhibits p300/GATA4-induced hypertrophic response (P22)
12. Yuga Sugiyama, Nurmila Sari, Noriyuki Murata, Hikaru Sato, Yasufumi Katanasaka, Yusuke Miyazaki, Yoichi Sunagawa, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
    The natural compound zerumbone inhibits cardiomyocyte hypertrophy and fibrosis phenotype in vitro (P23)
13. Ebi haruka, Masafumi Funamoto, Yoichi Sunagawa, Yasufumi Katanasaka, Yusuke Miyazaki, Hiroki Honda, Kana Shimizu, Satoshi Shimizu, NURMILA Sari, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
    The 5-HT2A Receptor Antagonist Sarpogrelate Inhibits Pressure Overload-Induced Heart Failure (P24)
14. Asami Yabuta, Yoichi Sunagawa, Yusuke Miyazaki, Yasufumi Katanasaka, Hiromichi Wada, Akira Murakami, Akira Shimatsu, Koji Hasegawa, Tatsuya Morimoto
    Auraptene Prevents Cardiomyocyte Hypertrophy and the Development of Heart Failure (P29)
15. Hiroki Honda, Yusuke Miyazaki, Yasufumi Katanasaka, Yoichi Sunagawa, Masafumi Funamoto, Nurmila Sari, Satoshi Shimizu, Kana Shimizu, Chisato Ohba, Midori Natsume, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
    Cacao bean polyphenol inhibits cardiac dysfunction in pressure overload-induced heart failure model (P30)
16. Ayaka Ebe, Yoichi Sunagawa, Anna Suzuki, Masafumi Funamoto, Ryoga Sakurai, Yasufumi Katanasaka, Yusuke Miyazaki, Nobuya Inagaki, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
    Overexpression of NBP1 Prevents PE-Induced Phosphorylation of p38 and GATA4 in Cardiomyocytes (P31)
17. Ayumi Katayama, Masafumi Funamoto, Kana Shimizu, Mai Gempei, Yoichi Sunagawa, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
    Comparative analysis of the effects EPA and DHA (P34)
18. SHIMIZU Kiyotaka, Funamoto Masafumi, Katayama Ayumi, Shimizu Kana, Sunagawa Yoichi, Miyazaki Yusuke, Katanasaka Yasufumi, Wada Hiromichi, Hasegawa Koji, Morimoto Tatsuya
    Metformin Suppresses Cardiomyocyte Hypertrophy by Inhibiting p300 Histone Acetyltransferase Activity (P36)
19. Nurmila Sari, Yasufumi Katanasaka, Yuga Sugiyama, Hikaru Sato, Yusuke Miyazaki, Yuichi Sunagawa, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
    A natural compound alpha-mangostin inihibits cardiomyocyte hypertrophy and fibrosis (P37)
20. Moritake Iguchi, Shuichi Ura, Nobutoyo Masunaga, Mitsuru Ishii, Takashi Unoki, Hisashi Ogawa, Daisuke Takagi, Noriko Satoh-Asahara, Akira Shimatsu, Mitsuru Abe, Masaharu Akao, Koji Hasegawa, Hiromichi Wada
    Relationship between VEGF-C levels and all-cause mortality in patients with chronic heart failure (P39)
21. Masashi Tanaka, Hajime Yamakage, Takayuki Inoue, Kazuya Muranaka, Shinji Odori, Hiromichi Wada, Kazuhiko Kotani, Toru Kusakabe, Akira Shimatsu, Koji Hasegawa, Noriko Satoh-Asahara
    A Potential Marker of Cognitive Impairment in Diabetic Patients:Pathological Significance of TREM2 (P60)
22. Sayaka Shimada, Maki Komiyama, Hiromichi Wada, Hajime Yamakage, Yoichi Sunagawa, Tatsuya Morimoto, Yuka Ozaki, Akira Shimatsu, Yuko Takahashi, Koji Hasegawa
    The impact of weight gain after quitting smoking on Adiponectin levels (P62)
23. Masahiro Watanabe, Yokichi Ajiro, Fumiaki Mori, Kazunori Iwabe, Hiroyuki Tanaka, Kouji Hasegawa, Hiromichi Wada, Nobuhisa Hagiwara, Ryusuke Furuya, Naoki Sekiguchi, NHOC-PCPS study investigators
    the study of daily predict score of weaning of VA-ECMO
24. Tatsuya Morimoto, Yoichi Sunagawa, Yasufumi Katanasaka, Yusuke Miyazaki, Hiromichi Wada, Koji Hasegawa
    Effect of Highly Absorptive Curcumin on Left Ventricular Diastolic Function

国内学会

第126回日本循環器学会近畿地方会2018年11月24日大阪 (3演題)

1. 土井康佑, 石井充, 石上健二郎, 青野佑哉, 池田周平, 安珍守, 井口守丈, 小川尚, 益永信豊, 和田啓道, 中島康代, 長谷川浩二, 阿部充, 赤尾昌治,
   子宮筋腫の偽閉経療法中に発症した特発性冠動脈解離の一例 (B-2, 抄録P51)
2. 石上健二郎, 安珍守, 青野佑哉, 池田周平, 土井康佑, 石井充, 井口守丈, 小川尚, 益永信豊, 和田啓道, 中島康代, 長谷川浩二, 阿部充, 赤尾昌治.
   偽性心室頻拍を合併した中隔副伝導路に対してアブレーション治療を施行した一例 (E-15, 抄録P80)
3. 生野智美, 土井康佑, 石上健二郎, 池田周平, 青野佑哉, 安珍守, 石井充, 井口守丈, 小川尚, 益永信豊, 中島康代, 和田啓道, 長谷川浩二, 阿部充, 赤尾昌治.
   臨床的経過に差を認めた左前下行枝近位部閉塞による急性心筋梗塞症例の比較検討 (F-9, 抄録P85)

第22回日本心不全学会学術集会 2018年10月11-13日 東京

1. 村田 謄行, 刀坂 泰史, 宮崎 雄輔, 砂川 陽一, 和田 啓道, 長谷川 浩二, 森本 達也
   心臓線維化反応におけるWDR5/MLL1メチル化酵素複合体の機能解析
2. 清水 圭貴, 船本 雅文, 清水 果奈, 片山 歩美, 砂川 陽一, 宮崎 雄輔, 刀坂 泰史, 和田 啓道, 長谷川 浩二, 森本 達也
   ビグアナイド系糖尿病治療薬メトホルミンはフェニレフリン刺激による心筋細胞肥大を抑制した
3. 片山 歩美, 源平 麻衣, 清水 果奈, 船本 雅文, 砂川 陽一, 和田 啓道, 刀坂 泰史, 宮崎 雄輔, 長谷川 浩二, 森本 達也
   ω-3系多価不飽和脂肪酸であるEPA, DHAによる心筋細胞肥大抑制作用の比較検討
4. 茂木 光, 清水 聡史, 砂川 陽一, 船本 雅文, Sari NUMILA, 清水 果奈, 宮崎 雄輔, 刀坂 泰史, 小郷 尚久, 浅井 章良, 和田 啓道, 長谷川 浩二, 森本 達也
   新生仔ラット初代培養心筋細胞肥大を指標にしたハイスループットスクリーニング系の確立

第2回日本循環器学会基礎研究フォーラム 2018年9月22, 23日 奈良 (1演題)

1. Yoichi Sunagawa, Yusuke Miyazaki, Yasufumi, Katanasaka, Toshiyuki Kan, Hiromichi Wada, KojiHasegawa1, Tatsuya Morimoto. A Novel Target Molecule of Nobiletin possess a Therapeutic Potency for Heart Failure in Mice (P08-7)

第125回日本循環器学会近畿地方会2018年6月30日大阪 (1演題)

1. 池田周平, 井口守丈, 小川尚, 青野佑哉, 土井康佑, 安珍守, 石井充, 益永信豊, 中島康代, 和田啓道, 長谷川浩二, 阿部充, 赤尾昌治
   心尖部血栓が残存した，たこつぼ型心筋症の１例 (抄録P83、F-26)

第61回日本糖尿病学会年次学術集会 2018年5月24日-26日 東京 (1演題)

1. 田中 将志, 増田 慎也, 山陰 一, 井上 隆之, 北野 隆司, 横田 繁史, 村中 和哉, 日下部 徹,和田 啓道, 真田 樹義, 石井 好二郎, 長谷川 浩二, 島津 章, 浅原 哲子
   肥満患者における骨格筋由来液性因子･マイオスタチンを介した耐糖能悪化と骨格筋萎縮 (a91499)　5月25日

第83回日本循環器学会学術集会 2018年03月23-25日 大阪（21演題）

1. Hiromichi Wada, Masahiro Suzuki, Morihiro Matsuda, Yoichi Ajiro, Tsuyoshi Shinozaki, Satoru Sakagami, Kazuya Yonezawa, Masatoshi Shimizu, Junichi Funada, Takashi Takenaka, Yukiko Morita, Toshihiro Nakamura, Kazuteru Fujimoto, Hiromi Matsubara, Toru Kato, Takashi Unoki, Daisuke Takagi, Kazuhiko Kotani, Mitsuru Abe, Masaharu Akao, Koji Hasegawa
   Vascular Endothelial Growth Factor-C and Cardiovascular and All-cause Mortality in Patients with Suspected Coronary Artery Disease: From the ANOX Study (PL7-1)
2. Hiromichi Wada, Tsuyoshi Shinozaki, Masahiro Suzuki, Satoru Sakagami, Yoichi Ajiro, Junichi Funada, Morihiro Matsuda, Masatoshi Shimizu, Takashi Takenaka, Yukiko Morita, Kazuya Yonezawa, Hiromi Matsubara, Yujiro Ono, Toshihiro Nakamura, Kazuteru Fujimoto, Kazuro Yoshida, Toru Kato, Moritake Iguchi, Kazuhiko Kotani, Noriko Asahara, Mitsuru Abe, Masaharu Akao, Koji Hasegawa
   Biomarkers Predicting the Presence of Coronary Artery Disease in Patients with and without Chronic Kidney Disease: The EXCEED-J Study (OE68-9)
3. 井口守丈, 浦修一, 益永信豊, 石井充, 鵜木崇, 小川尚, 髙木大輔, 浅原哲子, 島津章, 阿部充, 赤尾昌治, 長谷川浩二, 和田啓道
   Low VEGF-C was Independently Associated with All-cause and Cardiovascular Death among Patients with Chronic Heart Failure (OJ03-3)
4. Moritake Iguchi, Masahiro Suzuki, Morihiro Matsuda, Yoichi Ajiro, Tsuyoshi Shinozaki, Satoru Sakagami, Kazuya Yonezawa, Masatoshi Shimizu, Junichi Funada, Takashi Takenaka, Yukiko Morita, Kyohma Wada, Mitsuru Abe, Masaharu Akao, Koji Hasegawa, Hiromichi Wada
   High Serum-amyloid-A/LDL Predicts Angiographic Severity of Coronary Artery Disease in Patients with Heart Failure: Baseline Data from the ANOX Study (PE049-6)
5. 石井充, 小川尚, 益永信豊, 井口守丈, 安珍守, 江里正弘, 全栄和, 辻光, 和田啓道, 長谷川浩二, 阿部充, 赤尾昌治
   Hypertension and the Risk of Adverse Events in Patients with Atrial Fibrillation: The Fushimi AF Registry (SY20-3)
6. Yuya Aono, Moritake Iguchi, Kosuke Doi, Yoshimori An, Mitsuru Ishii, Nobutoyo Masunaga, Masahiro Esato, Hiromichi Wada, Koji Hasegawa, Hisashi Ogawa, Mitsuru Abe, Masaharu Akao
   Risk Factors for New-onset Heart Failure in Atrial Fibrillation Patients without Pre-existing Organic Heart Disease: The Fushimi AF Registry (FRS1-6)
7. Hisashi Ogawa, Yoshimori An, Shuhei Ikeda, Yuya Aono, Kosuke Doi, Mitsuru Ishii, Moritake Iguchi, Nobutoyo Masunaga, Masahiro Esato, Hikari Tsuji, Hiromichi Wada, Koji Hasegawa, Mitsuru Abe, Masaharu Akao
   Inappropriate Use of Direct Oral Anticoagulant is Associated with Increased Mortality Risk in Atrial Fibrillation Patients: The Fushimi AF Registry (FRS5-5)
8. Yoshimori An, Mitsuru Ishii, Moritake Iguchi, Nobutoyo Masunaga, Kosuke Doi, Yuya Aono, Shuhei Ikeda, Masahiro Esato, Hikari Tsuji, Hiromichi Wada, Koji Hasegawa, Hisashi Ogawa, Mitsuru Abe, Masaharu Akao
   Impact of Anemic Severity on Stroke/Systemic Embolism, Bleeding, and Cardiovascular Death in Patients with Atrial Fibrillation: The Fushimi AF Registry (FRS8-6)
9. Yoichi Sunagawa, Anna Suzuki, Asami Yabuta, Hana Sasaki, Masafumi Funamoto, Yasufumi Katanasaka, Yusuke Miyazaki, Tomohiro Asakawa, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
   A Novel Nobiletin Binding Protein 1, NBP1, is Required to Exhibit Therapeutic Potency of Nobiletin for Heart Failure in Mice (OE15-4)
10. Masaharu Akao, Syuhei Ikeda, Yuya Aono, Kosuke Doi, Yoshimori An, Mitsuru Ishii, Moritake Iguchi, Hisashi Ogawa, Nobutoyo Masunaga, Hiromichi Wada, Koji Hasegawa, Mitsuru Abe
    Patient Knowledge of Atrial Fibrillation and Anti-coagulant Therapy: TASK-AF Fushimi Pilot Program (OE20-7)
11. Kosuke Doi, Moritake Iguchi, Masahiro Esato, Hikari Tsuji, Hiromichi Wada, Koji Hasegawa, Hisashi Ogawa, Mitsuru Abe, Masaharu Akao
    Clinical Characteristics and Outcomes of Japanese Patients with Valvular versus Non-valvular Atrial Fibrillation: The Fushimi AF Registry (OE23-5)
12. Kana Shimizu, Masafumi Funamoto, Yoichi Sunagawa, Yasufumi Katanasaka, Yusuke Miyazaki, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
    Low Dose of a Curcumin Analogue, Y-030, Significantly Suppresses p300-HAT Activity and the Development of Heart Failure (OE37-7)
13. Hisashi Ogawa, Hiroaki Sugiyama, Yoshimori An, Moritake Iguchi, Shuhei Ikeda, Yuya Aono, Kosuke Doi, Mitsuru Ishii, Nobutoyo Masunaga, Masahiro Esato,Hikari Tsuji, Hiromichi Wada, Koji Hasegawa, Mitsuru Abe, Masaharu Akao
    Clinical Outcomes of Atrial Fibrillation Patients with Bifascicular Block: The Fushimi AF Registry (OE41-3)
14. Hisashi Ogawa, Hiroaki Sugiyama, Yoshimori An, Syuhei Ikeda, Yuya Aono, Kosuke Doi, Mitsuru Ishii, Moritake Iguchi, Nobutoyo Masunaga, Masahiro Esato,Hikari Tsuji, Hiromichi Wada, Koji Hasegawa, Mitsuru Abe, Masaharu Akao
    Clinical Characteristics and Prognosis of Atrial Fibrillation Patients with Fine Fibrillatory Wave: The Fushimi AF Registry (OE41-9)
15. Nobutoyo Masunaga, Hisashi Ogawa, Moritake Iguchi, Mitsuru Ishii, Yoshimori An, Kosuke Doi, Yuya Aono, Shuhei Ikeda, Masahiro Esato, Hikari Tsuji, Hiromichi Wada, Koji Hasegawa, Mitsuru Abe, Masaharu Akao
    Change of Antithrombotic Therapy in Atrial Fibrillation Patients with Combination of Oral Anti-coagulant and Antiplatelet Drug: The Fushimi AF Registry (OE49-2)
16. Masahiro Esato, Yoshimori An, Hiromichi Wada, Koji Hasegawa, Hisashi Ogawa, Mitsuru Abe, Masaharu Akao
    Catheter Ablation versus Antiarrhythmic Drugs for Atrial Fibrillation Rhythm-Control Therapy: A Propensity Score Matched Analysis from the Fushimi AF Registry (OE55-2)
17. Moritake Iguchi, Hisashi Ogawa, Nobutoyo Masunaga, Mitsuru Ishii, Yoshimori An, Kosuke Doi, Syuhei Ikeda, Yuya Aono, Masahiro Esato, Hikari Tsuji, Hiromichi Wada, Koji Hasegawa, Mitsuru Abe, Masaharu Akao
    Risk Factors of Hospitalization for Heart Failure in Patients with Atrial Fibrillation and Pre-existing Heart Failure: The Fushimi AF Registry (OE78-2)
18. Mitsuru Abe, Hisashi Ogawa, Syuhei Ikeda, Yuya Aono, Kosuke Doi, Yoshimori An, Mitsuru Ishii, Moritake Iguchi, Nobutoyo Masunaga, Masahiro Esato, Hikari Tsuji, Hiromichi Wada, Koji Hasegawa, Masaharu Akao
    The Incidence and Risk Factors of Percutaneous Coronary Intervention Procedures in Patients with Atrial Fibrillation: The Fushimi AF Registry (PE017-2)
19. Yoshimori An, Mitsuru Ishii, Moritake Iguchi, Nobutoyo Masunaga, Kosuke Doi, Yuya Aono, Shuhei Ikeda, Masahiro Esato, Hikari Tsuji, Hiromichi Wada, Koji Hasegawa, Hisashi Ogawa, Mitsuru Abe, Masaharu Akao
    Usefulness of the CHA2DS2-VASc Score in Predicting Stroke and Cardiovascular Death in Patients with Atrial Fibrillation: The Fushimi AF Registry (PE091-4)
20. Masaharu Akao, Syuhei Ikeda, Yuya Aono, Kosuke Doi, Yoshimori An, Mitsuru Ishii, Moritake Iguchi, Hisashi Ogawa, Nobutoyo Masunaga, Hiromichi Wada, Koji Hasegawa, Mitsuru Abe
    Association between Patient Knowledge and Treatment Satisfaction in Patients with Atrial Fibrillation Receiving Anticoagulant Therapy: TASK-AF Fushimi Pilot Program (PE113-4)
21. Satoshi Shimizu, Kodai Hara, Yoichi Sunagawa, Asami Hishiki, Masafumi Funamoto, Yusuke Miyazaki, Yasufumi Katanasaka, Hiromichi Wada, Koji Hasegawa, Hiroshi Hashimoto, Tatsuya Morimoto
    The Dimerization Domain of the Hypertrophy-responsive Transcription Factor GATA4 is a Therapeutic Target for Heart Failure (PE131-3)

第1回日本循環器学会基礎研究フォーラム 2018年1月6, 7日 東京 (4演題)

1. Yoichi Sunagawa, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto, et al.
   Novel GATA4 Binding Proteins, RbAp48/46 are Involved in Hypertrophic Responses in Cardiomyocytes (10037-4)
2. Yasufumi Katanasaka, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto, et al.
   Cardiac PRMT5 accelerates pressure overload-induced cardiac hypertrophy and heart failure (10086-4)
3. Kana Shimizu, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto, et al.
   Curcumin analogue, GO-Y030, prevent the development of heart failure more strongly than curcumin (10095-8)
4. Satoshi Shimizu, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto, et al.
   Dimerization of GATA4 plays an important role in the development cardiomyocyte hypertrophy (10127-8)

国内研究会

16th Stroke Oriented…研究会 2018年9月1日 京都

• 一般講演
  和田　啓道
  脳卒中の危険因子としての慢性腎臓病

第16回京都心血管フォーラム 2018年1月6日 京都

1. 和田　啓道, 鈴木　雅裕, 松田　守弘, 網代　洋一, 篠崎　毅, 阪上　学, 米澤　一也, 清水　雅俊, 舩田　淳一, 竹中　孝, 森田有紀子, 中村　俊博, 藤本　和輝, 松原　広己, 加藤　徹, 鵜木　崇, 高木　大輔, 浦　修一, 和田　享万, 井口　守丈, 益永　信豊, 石井　充, 山陰 一, 島津　章, 小谷　和彦, 浅原　哲子, 阿部　充, 赤尾　昌治, 長谷川　浩二
   VEGF-C and Mortality in Patients with Suspected Coronary Artery Disease
2. 土井　康佑, 石井　充, 青野　佑哉, 池田　周平, 安　珍守, 井口　守丈, 小川　尚, 益永　信豊, 和田　啓道, 中島　康代, 長谷川　浩二, 阿部　充, 赤尾　昌治
   心嚢水多量で搬送となり急速に心機能悪化を認めた好酸球性心筋炎の一例

→先端医療技術開発研究室 (心血管リスクとバイオマーカー研究グループ)