臨床研究センター

先端医療技術開発研究室

2012年　国際学会・国内学会・研究会　発表

国際学会

American Heart Association Scientific Sessions 2012 Nov 3-7 Los Angeles CA USA

• Nobutoyo Masunaga, Hiromichi Wada, Masaharu Akao, Shuichi Ura, Mitsuru Ishii, Takashi Unoki, Mitsuru, Abe, Mikhiko Kanasaki, Yasuyo Nakashima, Koh Ono, Tatsuya Morimoto, Noriko Asahara, Akira Shimatu, Koji Hasegawa
  Serum Levels of Vascular Endothelial Growth Factor-C are Inversely Correlated with Future Cardiovascular Events (Program p168)
• Takashi Unoki,Hiromichi Wada, Masaharu Akao, Suichi Ura, Nobutoyo Masunaga, Mitsuru Ishii, Mitsuru, Abe, Hisashi Ogawa, Moritake Iguchi, Yoshika Takenaka, Kensuke Takabayashi, Yasuyo Nakajima, Mikihiko Kanasaki, Genta Osakada, Akira Shimatsu, Koji Hasegawa
  Serum Levels of Vascular Endothelial Growth Factor-C are Inversely Correlated with Severe Coronary Artery Disease (Program p196)
• Mitsuru Ishii, Hiromichi Wada, Masaharu Akao, Shuichi Ura, Nobutoyo Masunaga, Takashi Unoki, Mitsuru, Abe, Yasuyo Nakashima, Mikihiko Kanasaki, Genta Osakada, Noriko Satoh Asahara, Akira Shimatsu, Koji Hasegawa
  Serum Levels of VEGF-C, but not VEGF-A, are Inversely Correlated with Systolic Dysfunction (Program p307)
• Shuichi Ura, Hiromichi Wada, Shuji Kitaoka, Noriko Satoh-Asahara, Takahiro Horie, Koh Ono, Tomohide Takaya,, Rieko Takanabe-Mori, Masaharu Akao, Mitsuru Abe, Tatsuya Morimoto, Toshinori Murayama, Masayuki Yokode, Masatoshi Fujita, Akira Shimatsu, Koji Hasegawa
  Circulating Levels of Vascular Endothelial Growth Factor-C are Closely Associated with Dyslipidemia and Atherosclerosis (Program p445)
• Hiromichi Wada, Shuichi Ura, Nobutoyo Masunaga, Masaharu Akao, Mitsuru Ishii, Takashi Unoki, Mitsuru Abe, Yasuyo Nakajima, Mikihiko Kanasaki, Koh Ono, Tatsuya Morimoto, Noriko Satoh-Asahara, Akira Shimatsu, Koji Hasegawa
  Soluble Vascular Endothelial Growth Factor Receptor-1 as a Predictor of Cardiovascular Events in Stable Outpatients with Chronic Kidney Disease (Program p577)
• Masaharu Akao, Yeong-Hwa Chun, Hiromichi Wada, Masahiro Esato, Tetsuo Hashimoto, Mitsuru Abe, Koji Hasegawa, Hikari Tsuji, Keizo Furuke; The Fushimi AF Registry Investigators
  Current Status of Clinical Background of Hemodialysis Patients with Atrial Fibrillation in Japan: From the Fushimi Af Registry (Program p578)
• Yoichi Sunagawa, Yasufumi Katanasaka, Yuichi Watanabe, Hidetoshi Suzuki, Naruto Hajika,Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  Retinoblastoma Protein-associated Protein 48 and 46 Form Repressor Complex With p300/GATA4 And Inhibit Hypertrophic Responses in Cardiomyocytes (Program p460)

European Society of Cardiology Congress 2012 Aug 25-29 Munich Germany

• N. Masunaga, H. Wada, M. Akao, S. Ura, M. Abe, M. Ishii, T. Unoki, Y. Takahashi, A. Shimatsu, K. Hasegawa
  Serum levels of alpha1-antitrypsin-low-density-lipoprotein are associated with smoking and severe arteriosclerosis obliterans [P1596, Program p104]
• N. Masunaga, H. Wada, M. Akao, S. Ura, M. Abe, G. Osakada, T. Morimoto, N. Satoh-Asahara, A. Shimatsu, K. Hasegawa
  Serum levels of placental growth factor is associated with left ventricular hypertrophy in men [P1927, Program p120]
• H. Ogawa, M. Akao, Y.H. Chun, H. Wada, M. Esato, H. Tsuji, M. Abe, N. Masunaga, M. Ishii, K. Hasegawa
  Clinical significance of bundle branch block in patients with atrial fibrillation: From the Fushimi AF Registry [P2317, Program p144]
• H. Wada, S. Ura, M. Akao, N. Masunaga, M. Abe, M. Ishii, T. Unoki, G. Osakada, A. Shimatsu, K. Hasegawa
  Soluble vascular endothelial growth factor receptor-2, but not vascular endothelial growth factor, is decreased in sera from patients with left ventricular hypertrophy and systolic dysfunction [P5130, Program p295]
• H. Wada, N. Masunaga, S. Ura, M. Akao, M. Abe, Y. Fujita, Y. Satoh, A. Shimatsu, T. Sawamura, K. Hasegawa
  Index of lectin-like oxidized low-density-lipoprotein receptor is independently associated with left ventricular systolic dysfunction [P5151, Program p296]

Cell Symposia: Angiogenesis, Metabolic Regulation, and Cancer Biology 6-8 Jul 2012 Leuven Belgium

• Hiromichi Wada, Shuichi Ura, Shuji Kitaoka, Noriko Satoh-Asahara, Takahiro Horie, Koh Ono, Tomohide Takaya, Rieko Takanabe-Mori, Masaharu Akao, Mitsuru Abe,Tatsuya Morimoto, Toshinori Murayama, Masayuki Yokode, Masatoshi Fujita, Akira Shimatsu, and Koji Hasegawa
  Serum levels of VEGF-C, rather than VEGF-A, are closely related to dyslipidemia and atherosclerosis

The XVIIth International Congress of ISCP (International Society of Cardiovascular Pharmacology) 4-5 May 2012 Bucharest Romania

• Shuichi Ura, Hiromichi Wada, Noriko Satoh-Asahara, Koh Ono1, Tatsuya Morimoto, Akira Shimatsu, Koji Hasegawa
  The combination therapy of imidapril and simvastatin significantly reduces serum levels of soluble vascular endothelial growth factor receptor-2 in the rat model of metabolic syndrome (Abstract II-4-Y)
• Sunagawa Y, Suzuki H, Katanasaka Y, Wada H, Fujita M, Hasegawa K, Morimoto T.
  Serotonin type 2A receptor-dependent pathway plays important roles in phenylephrine-induced hypertrophic response in cardiomyocytes (Abstract I-5-Y)
• Sunagawa Y, Morimoto T, Suzuki H, Wada H, Kakeya H, Hashimoto T, Hasegawa K.
  A natural p300 hat inhibitor, curcumin, prevents the development of hypertension-induced left ventricular hypertrophy in rats (Abstract III-3-Y)
• Sunagawa Y, Suzuki H, Katanasaka Y, Wada H, Hashimoto K, Hasegawa K, Morimoto T.
  Nobiletin derived from a citrus flavonoid prevents the deterioration of systolic function after myocardial infarction in rats (Abstract III-5-Y)

World Congress of Cardiology Scientific Sessions 2012 April 18-21 Dubai, United Arab Emirates

• Suichi Ura, Hiromichi Wada, Masaharu Akao, Nobutoyo Masunaga, Mitsuru Abe, Mitsuru Ishii, Takashi Unoki, Genta Osakada, Akira Shimatsu, Koji Hasegawa
  Serum levels of soluble VEGF receptor-2, but not those of VEGF, are decreased in patients with left ventricular hypertrophy and systolic dysfunction (WCC12-ABS-1529 P088)

American College of Cardiology Scientific Session 2012 Mar 24-26 Chicago IL USA

• Tatsuya Morimoto, Hiromichi Wada, Yoichi Sunagawa, Masatoshi Fujita, Hideaki Kakeya, Atsushi Imaizumi, Tadashi Hashimoto, Masaharu Akao, Yasufumi Katanasaka, Genta Osakada, Hirofumi Kambara, Hiroki Shiomi, Takeshi Kimura, Akira Shimatsu, Koji Hasegawa
  Highly absorptive curcumin improves left ventricular diastolic function regardless of blood pressure in hypertensive patients

国内学会

第20回日本血管生物医学会　2012年12月5－7日　徳島

• Takashi Unoki, Hiromichi Wada, Masaharu Akao, Suichi Ura, Nobutoyo Masunaga, Mitsuru Ishii, Mitsuru Abe, Hisashi Ogawa, Moritake Iguchi, Yoshika Takenaka, Kensuke Takabayashi, Yasuyo Nakajima, Mikihiko Kanasaki, Genta Osakada, Akira Shimatsu, Koji Hasegawa
  An Inverse Correlation between Serum VEGF-C Levels and Severity of Coronary Artery (O-1, Abstract P92)
• Nobutoyo Masunaga, Hiromichi Wada, Suichi Ura, Masaharu Akao, Mitsuru Ishii, Takashi Unoki, Mitsuru Abe, Yuko Takahashi, Akira Shimatsu, Koji Hasegawa
  Serum Levels of α1-Antitrypsin-low-density-lipoprotein are Increased in Sera from Patients with Severe Arteriosclerosis Obliterans (P-8, Abstract P116)

第7回日本禁煙科学会　2012年11月17－18日　盛岡

• 浦　修一、和田　啓道、小谷　和彦、浅原（佐藤）　哲子、島津　章、高橋　裕子、長谷川　浩二
  血清Lp-PLA2 massレベルは禁煙により有意に低下する (G-2, Abstract P82)
• 小見山　麻紀、和田　啓道、浦　修一、山陰　一、浅原　哲子、嶋田　清香、島津　章、小山　弘、河野　公一、高橋　裕子、長谷川　浩二
  心血管リスクバイオマーカーに対する禁煙後肥満の影響 (G-1, Abstract P82)
• 嶋田　清香、長谷川　浩二、和田　啓道、寺嶋　幸子、浅原　哲子、山陰　一、赤尾　昌治、長岡　野亜、飯田　夕子、島津　章、高橋　裕子
  禁煙1 年後の血液流動性の変化について (G-1, Abstract P83)
• 嶋田　清香、和田　啓道、浦　修一、寺嶋　幸子、浅原　哲子、山陰　一、小見山　麻紀、赤尾　昌治、島津　章、高橋　裕子、長谷川　浩二
  禁煙患者における血液流動性とSAA-LDL, AT-LDL の検討 (G-4, Abstract P83)
• 長岡　野亜、和田　啓道、飯田　夕子、嶋田　清香、小見山　麻紀、寺嶋　幸子、山陰　一、浅原　哲子、島津　章、高橋　裕子、長谷川　浩二
  禁煙による酸化状態の改善について―唾液酸化還元電位値の測定による検討 (P-3 Abstract P85)

第33回日本肥満学会 2012年10月11-12日　京都

• 浦　修一,　和田　啓道,　北岡　修二,　浅原　哲子,　堀江　貴裕,　尾野　亘,　赤尾　昌治,　阿部　充,　森本　達也,　村山　敏典,　横出　正之,　島津　章,　長谷川　浩二
  血管内皮増殖因子Cと脂質異常・動脈硬化との関連 (O-096, Abstract P157)
• 和田　啓道, 浦　修一,　赤尾　昌治,　益永　信豊, 高谷　智英, 森　利依子,　小坂田　元太,　浅原　哲子, 島津　章, 長谷川　浩二
  血清アディポネクチンレベルと左室肥大の関連 (P-038, Abstract P176)
• 浦　修一, 和田　啓道, 浅原 哲子, 尾野　亘, 森本　達也, 島津　章, 長谷川浩二
  Imidaprilとsimvastatinの併用は血清可溶性VEGF受容体2レベルを低下させる (P-253, Abstract P213)
• 和田　啓道,　益永　信豊,　赤尾　昌治,　浦　修一,　石井　充,　鵜木崇,　阿部　充,　浅原哲子,　島津　章,　長谷川　浩二
  酸化変性LDL、 α1-antitrypsin-LDLと閉塞性動脈硬化症の関連 (P-259, Abstract P214)

第60回日本心臓病学会学術集会 2012年9月14-16日　金沢

• 浦　修一、和田　啓道、小谷　和彦、山田　明、浅原（佐藤）　哲子、島津　章、高橋　裕子、長谷川　浩二
  禁煙が血清Lp-PLA2 massレベルに及ぼす影響 (O-100, Program P182)
• 鵜木　崇、和田　啓道、赤尾　昌治、浦　修一、阿部　充、益永　信豊、石井　充、小川　尚、井口　守丈、高林　健介、中島　康代、金崎　幹彦、小坂田　元太、島津　章、長谷川　浩二
  貧血を伴う慢性腎臓病は、重症冠動脈疾患の独立した規定因子である (P-443, Program P386)
• 石井　充、和田　啓道、浦　修一、赤尾　昌治、阿部　充、益永　信豊、鵜木　崇、小坂田　元太、金崎　幹彦、中島　康代、島津　章、長谷川　浩二
  左室肥大を有さない耐糖能異常・軽度糖尿病患者において僧房弁E/A比は血清高感度CRPレベルと有意な負の相関を認める (P-451, Program P388)

第44回日本動脈硬化学会 2012年7月19-20日　福岡

• Hiromichi Wada, Shuichi Ura, Shuji Kitaoka, Satoh-Asahara, Takahiro Horie, Koh Ono, Masaharu Akao, Mitsuru Abe, Tatsuya Morimoto, Toshinori Murayama, Masayuki Yokode , Akira Shimatsu, Koji Hasegawa
  Serum vascular endothelial growth factor-C levels are associated with dyslipidemia and atheroscrelosis (高得点演題に採択) (HS-28, Program P81)
• Hiromichi Wada, Nobutoyo Masunaga, Masaharu Akao, Suichi Ura, Mitsuru Ishii, Takashi Unoki, Mitsuru Abe, Yuko Takahashi, Akira Shimatsu, Koji Hasegawa
  α1-Antitrypsin-low-density-lipoprotein, a smoking-related oxidatively modified LDL, is increased in sera from patients with severe arteriosclerosis obliterans (P-84, Program P72)

第55回日本糖尿病学会　2012年5月17-19日　横浜

• 浦　修一, 和田　啓道, 北岡　修二, 浅原 (佐藤)　哲子, 堀江貴裕, 尾野　亘, 高谷　智英, 森 (高鍋)　利依子, 赤尾　昌治, 阿部　充, 森本　達也, 藤田　正俊, 島津　章, 長谷川　浩二
  血管内皮増殖因子Cは脂質異常及び動脈硬化と関連している (I-9-12 抄録S-89 )
• 益永 信豊, 和田　啓道, 浦　修一, 赤尾 昌治, 石井 充, 鵜木 崇, 阿部 充, 小川 尚, 竹中 淑夏, 中島 康代, 金崎 幹彦, 浅原(佐藤）哲子, 島津 章, 長谷川 浩二
  喫煙に密接に関連したα1-anti-trypsin-LDLの血中レベルは閉塞性動脈硬化症で上昇する (III-P-24抄録S-324 )
• 和田　啓道, 尾野 亘, 浅原（佐藤）哲子, 川村 晃久, 森本 達也, 上北 和実, 東堂 龍平, 山田 和範, 赤尾 昌治, 小坂田 元太, 島津 章, 長谷川 浩二
  プラバスタチンもしくはアトルバスタチンとロサルタンの併用が耐糖能障害患者の心血管病変に及ぼす影響 (III-P-295抄録S-358 )
• 浅原 哲子, 佐々木 洋介, 橡谷 真由, 村中 和哉, 山陰 一, 河野 茂夫, 和田　啓道, 長谷川浩二, 島津 章
  メタボリック症候群におけるEPAの抗動脈硬化作用の分子機序―単球・マクロファージPPARγを介するIL-10の上昇作用― (II-8-24抄録S-175 )

第49回日本臨床分子医学会学術集会2012年4月13-14日　京都

• 和田 啓道, 浦　修一,　赤尾 昌治,　益永 信豊, 高谷 智英, 森 利依子,　小坂田 元太,　浅原(佐藤) 哲子, 島津 章, 長谷川 浩二
  血清アディポネクチンレベルは病的な左室肥大の誘導により上昇する (抄録p83)
• 砂川 陽一, 渡辺 雄一, 鈴木 秀敏, 刀坂 泰史, 和田 啓道, 島津 章, 木村 剛, 藤田 正俊, 長谷川 浩二, 森本 達也
  リプレッサーコンプレックスの構成因子であるRbAp48/46はp300/GATA4経路を介して心筋細胞肥大反応を抑制する

第76回日本循環器学会学術集会 2012年3月16-18日　福岡

• Takashi Unoki, Hiromichi Wada, Masaharu Akao, Suichi Ura, Nobutoyo Masunaga, Mitsuru Ishii, Mitsuru Abe, Hisashi Ogawa, Moritake Iguchi, Yoshika Takenaka, Kensuke Takabayashi, Yasuyo Nakajima, Mikihiko Kanasaki, Genta Osakada, Akira Shimatsu, Koji Hasegawa
  Serum Levels of Vascular Endothelial Growth Factor-C are Inversely Associated with Severe Coronary Artery Disease (OE-056抄録p190 )
• Nobutoyo Masunaga, Hiromichi Wada, Masaharu Akao, Shuichi Ura, Mitsuru Ishii, Takashi Unoki, Mitsuru Abe, Yasuyo Nakajima, Mikihiko Kanasaki, Koh Ono, Tatsuya Morimoto, Noriko Satoh-Asahara, Akira Shimatsu, Koji Hasegawa
  Serum Levels of Vascular Endothelial Growth Factor-C are Inversely Associated with Future Cardiovascular Events (PJ-311抄録p345 )
• Mitsuru Ishii, Hiromichi Wada, Masaharu Akao, Shuichi Ura, Nobutoyo Masunaga, Takashi Unoki, Mitsuru Abe, Yasuyo Nakajima, Mikihiko Kanasaki, Genta Osakada, Noriko Satoh-Asahara, Akira Shimatsu, Koji Hasegawa
  Serum Levels of VEGF-C, but not VEGF-A, are Inversely Associated with Systolic Dysfunction (PE-215抄録p432 )
• Shuichi Ura,Hiromichi Wada, Shuji Kitaoka, Noriko Satoh-Asahara, Takahiro Horie, Koh Ono, Tomohide Takaya, Rieko Takanabe-Mori, Masaharu Akao, Mitsuru Abe, Tatsuya Morimoto, Masatoshi Fujita, Akira Shimatsu, Koji Hasegawa
  Serum Levels of Vascular Endothelial Growth Factor-C are Associated with Dyslipidemia and Atheroscrelosis (OJ-152抄録p526 )
• Hiromichi Wada, Shuichi Ura, Nobutoyo Masunaga, Masaharu Akao, Mitsuru Ishii, Takashi Unoki, Mitsuru Abe, Mikihiko Kanasaki, Yasuyo Nakashima, Koh Ono, Tatsuya Morimoto, Akira Shimatsu, Koji Hasegawa.
  Soluble Vascular Endothelial Growth Factor Receptor-1 is a Novel Marker of Cardiovascular Risk in Association with Chronic Kidney Disease (FRS-080抄録p513)
• Hidetoshi Suzuki, Yoichi Sunagawa, Noriyuki Murai, Yasufumi Katanasaka, Sei-ichiro Yabuki, Shogo Kawaguti, Hiromichi Wada, Takeshi Kimura, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  5HT2A Receptor Antagonist, Sarpogrelate, Inhibited the Development of Phenylephrine-induced Hypertrophy in Cultured Cardiomyocytes (OE-209抄録p517)
• Rieko Takanabe-Mori, Koh Ono, Hiromichi Wada, Tomohide Takaya, Hajime Yamakage, Noriko Satoh-Asahara, Akira Shimatsu, Yuko Takahashi, Masatoshi Fujita, Yoshiko Fujita, Tatsuya Sawamura, Koji Hasegawa
  Possible Roles of Lectin-like Oxidized Low-density Lipoprotein Receptor-1 (LOX-1) in Smoking-induced Inflammation (OE-322抄録p647)
• Tatsuya Morimoto,Hiromichi Wada, Yoichi Sunagawa, Masatoshi Fujita, Hideaki Kakeya, Hiroki Sasaki, Atsushi Imaizumi, Tadashi Hashimoto, Masaharu Akao, Hidetoshi Suzuki, Yasufumi Katanasaka, Genta Osakada, Hirofumi Kanbara, Osamu Doi, Hiroko Shiomi, Takeshi Kimura, Akira Shimatsu, Koji Hasegawa
  Highly Absorptive Curcumin Improves Left Ventricular Diastolic Function in Hypertensive Patients with Left Ventricular Hypertrophy (OE-334抄録p649)
• Masatoshi Namiki, Yasufumi Katanasaka, Yoichi Sunagawa, Hidetoshi Suzuki, Sho Hirota, Yukiko Nakagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  Transducin Beta-like Protein 1 Suppresses Hypertrophic Responses through Repression of p300/GATA4 Pathway in Cardiomyocytes (PE-016抄録p203)
• Yoichi Sunagawa, Yukihiro Ishibashi, Natsumi Banno, Yasufumi Katanasaka, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  Human SNF5/INI1, a Component of the Human SWI/SNF Chromatin Remodeling Complex, Inhibits Hypertrophic Responses by Suppressing p300/GATA4-dependent Pathways in Cardiomyocytes (PE-260抄録p535)
• Masaharu Akao, Yeong-Hwa Chun, Hiromichi Wada, Masahiro Esato, Tetsuo Hashimoto, Mitsuru Abe, Koji Hasegawa, Hikari Tsuji, Keizo Furuke
  Current Status of Clinical Backgrounds of Patients with Atrial Fibrillation in a Community-based Prospective Survey: The Fushimi AF Registry (PE-398抄録p667)
• Yoichi Sunagawa Yuichi Watanabe, Hidetoshi Suzuki, Yasufumi Katanasaka, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  Retinoblastoma Protein (Rb)-associated Protein 48 and 46, Novel p300/GATA4-binding Partners, Inhibits Hypertrophic Responses in Cardiomyocytes (PJ-345抄録p444)
• Hisashi Ogawa, Mikihiko Kanasaki, Kensuke Takabayashi, Yoshika Takenaka, Takashi Unoki, Mitsuru Ishii, Moritake Iguchi, Nobutoyo Masunaga, Yasuyo Nakashima, Genta Osakada, Hiromichi Wada, Koji Hasegawa, Mitsuru Abe, Masaharu Akao
  Long-term Clinical Outcomes of Right Ventricular Septal Pacing Compared with Right Ventricular Apical Pacing in Patients with Pacemaker Implantation (PJ-411抄録p455)
• Hikari Tsuji, Masaharu Akao, Yeong-Hwa Chun, Hiromichi Wada, Masahiro Esato, Tetsuo Hashimoto, Mitsuru Abe, Koji Hasegawa, Keizo Furuke
  Distinct Difference in Clinical Backgrounds of Atrial Fibrillation Patients between Private Clinics and Cardiovascular Centers: From the Fushimi AF Registry (PJ-571抄録p565)
• Sayaka Shimada, Koji Hasegawa, Hiromichi Wada, Sachiko Terashima, Noriko Asahara-Satoh, Hajime Yamakage, Shuji Kitaoka, Akao Masaharu, Akira Shimatsu, Yuko Takahashi
  Obesity-associated Hyperlipidemia Perturbs Improvement of Blood Fluidity after Smoking Cessation (PJ-911抄録p799)

第10回 京都心血管疾患フォーラム2012年1月8日　京都 (演題23)

• 和田　啓道、浦　修一、益永　信豊、赤尾　昌治、阿部　充、石井　充、鵜木　崇、中島　康代、金崎　幹彦、尾野　亘、森本　達也、浅原　哲子、島津　章、長谷川　浩二
  可溶性VEGF受容体1 (sFlt-1) は慢性腎臓病 (CKD) 患者の心血管リスク指標である (臨床研究部門　第3位)

研究会

伏見循環器疾患Lecture meeting 2012年8月10日　京都

• 和田　啓道
  循環器疾患外来診療のポイント「高血圧・脂質異常（一次予防）」（講演）

→先端医療技術開発研究室 (心血管リスクとバイオマーカー研究グループ)